Improving Tumor‐to‐Background Contrast through Hydrophilic Tetrazines: The Construction of 18 F‐Labeled PET Agents Targeting Nonsmall Cell Lung Carcinoma
نویسندگان
چکیده
منابع مشابه
Update in PET imaging of nonsmall cell lung cancer.
u m b n i t w a o v o c n a e i ONSMALL CELL Lung cancer (NSCLC) is the leading cause of cancer death in both en and women in the United States. Despite ontinuing developments in diagnosis and treatent, the mortality from lung cancer remains high, ith an overall 5-year survival rate of only 15%.1 he primary treatment of lung cancer is surgery, nd the best chance for a complete cure comes rom to...
متن کاملTherapeutic options targeting angiogenesis in nonsmall cell lung cancer.
There is a major unmet medical need for effective and well-tolerated treatment options for patients with advanced nonsmall cell lung cancer (NSCLC), in both first-line and relapsed/refractory settings. Experimental evidence has validated signalling pathways that regulate tumour angiogenesis, including the vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and fibro...
متن کاملManagement of EGFR mutated nonsmall cell lung carcinoma patients.
Tyrosine kinase inhibitors (TKIs) targeting the epidermal growth factor receptor (EGFR) are common in the therapeutic armentarium of lung cancer today. Initially tested in an unselected population, they have been of limited usefulness until the identification EGFR gene mutations. Activating mutations generate conformational changes that result in a shift toward an active state of the catalytic ...
متن کاملDisturbance of systemic antioxidant profile in nonsmall cell lung carcinoma.
The present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC). A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were ...
متن کاملSevere haemoptysis in patients with nonsmall cell lung carcinoma.
Severe haemoptysis due to nonsmall cell lung cancer (NSCLC) is considered a grim condition, and there is still scarce data on its characteristics and outcome, despite new imaging and treatment modalities. This retrospective study sought to describe the clinical characteristics, pathophysiology and outcome of NSCLC-related haemoptysis. We included 125 consecutive patients with severe haemoptysis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2020
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.202000028